Nitrous Oxide Inhalation Sedation (Laughing Gas)

Photo of a patient receiving nitrous oxide

Inhalation sedation goes by many names such as: laughing gas, happy gas, nitrous, nitrous oxide and N2O-O2. Inhalation sedation with nitrous oxide (N2O) and oxygen (O2) is the most commonly used sedation technique in dentistry.

Nitrous oxide is effective for mild to moderate fear and anxiety and can be combined with an oral sedative to deepen the sedation.


How does nitrous oxide work?

Nitrous oxide (N2O) is a gas which you can breathe. It is colorless, odorless and doesn’t irritate. It is mixed with Oxygen in a device call a regulator to achieve proper concentration.

Nitrous oxide simply helps reduce pain and it gives you a pleasurable, tingly feeling. After breathing the gas for about 5 minutes you will feel a light headed sensation that will spread to your entire body.  It feels like a getting a buzz after a few drinks. Some people will react to the light headedness by giggling or laughing. Thus the term laughing gas.

N2O suppress almost all forms of sensation – especially hearing, touch and pain.  The ability to concentrate or perform intelligent acts is only minimally affected, as is memory.

How is nitrous oxide administered?

Nitrous Oxide machine

Nitrous oxide is delivered via a hose from the source to a nitrous oxide mask that fits over your nose.  The nitrous mask serves two functions.  One to deliver the gas and the other is remove excess gas so your dentist won’t breathe it.

All you have to do is breath thru your nose to inhale the gas.  The gases are mixed by a device called a regulator shown here.


Advantages of Nitrous Oxide

  • Nitrous oxide works quickly – it arrives in the brain in about 20 seconds and the effects of the gas begin within 2 to 3 minutes.
  • The degree of sedation can be adjusted easily for achieving the proper effect.
  • The effects of the gas are eliminated from your system within 5 minutes.  You will be able to safely drive home or back to work
  • Nitrous oxide sedation is very safe. There are very few know side effects and the gas used has no ill effects on the heart, lungs, liver, kidneys, or brain.

Disadvantages of Nitrous Oxide

  • Some individuals may feel nauseated with the gas or uncomfortable with the way it makes them feel
  • Some people may not achieve acceptable levels of sedation with gas alone
  • If your nose is stopped up or if you have trouble breathing through your nose you will not be able to breathe in adequate amounts of nitrous oxide and oxygen

Are there any contraindications?

The main contraindications are few.  They include MS and emphysema.  Nitrous oxide is not indicated for pregnant patients.

Comparison of Sedation Types

Nitrous Oxide

(pill & nitrous)

IV Sedation

Chance of “waking up” or being alert during procedure You will be alert during procedure but feel woozy Yes No
Best Use Mild anxiety or fear; any length appointment Mild to moderate fear or anxiety; short to medium length appointments Moderate to severe fear or anxiety, medium to long length appointments
Medication Nitrous Oxide Only Halcion, or similar sedative drug, plus Nitrous Oxide IV administered medications
Monitoring BP, pulse, respiratory rate monitored by Dentist BP, pulse, respiratory rate monitored by Dentist Pulse oximetry, BP, pulse, respiratory rate monitored by Anesthesiologist
Effects on Gag Reflex None Reduction in gag reflex No gag reflex
Effects on memory of appointment None Moderate reduction of memory of appointment No memory of appointment
Six hour fasting food, no liquids 2hr prior to appointment No Yes Yes
Need adult responsible party for ride home and recovery No Yes Yes
Recovery period 20 minutes 6-8 hours 2-4 hours
Medically compromised patient Yes, depends on medical condition No Yes, Medical Doctor Anesthesia Certified present
Age restrictions All ages 18+ All ages determined by Anesthesiologist
Cost $ $$ $$$
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Imagecare Dental Group

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  • Academy of General Dentistry
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  • International Congress of Oral Implantologists

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